Dr. Larry Brilliant starred in a 1960s film that was a total flop. The movie was called Medicine Ball Caravan and it was a (sort of) documentary that followed Larry and a bunch of other hippies as they followed the touring busses of acts like the Grateful Dead.
But despite the commercial failure of this film I would posit that it lead, though somewhat indirectly, to the global eradication of Small Pox — the first disease ever to be eradicated from the face of the earth. That’s because after the filming ended, Larry kept the hippie caravan going until he reached India, and while there, joined the World Health Organization’s small pox eradication program. It’s a great story.